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Crucially, there is no established evidence base for efficacy at low doses specifically for inflammation, and the dose-response relationship for anti-inflammatory effects is unknown
Contributing factors include: A diet high in sugar and processed fats[1] Exposure to environmental toxins like air pollution, pesticides and heavy metals[2] Cigarette smoke[3] and alcohol use[4] Infections and chronic inflammation[5] Intense or prolonged physical exertion[6] Psychological stress[7] Biochemically, oxidative stress is marked by an imbalance between oxidants and antioxidants, disrupting cellular signaling, promoting inflammation and weakening mitochondrial function.[8] Over time, this imbalance can lead to cumulative molecular damage, a foundational factor in aging and disease progression
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doi: 10.1038/sigtrans.2017.23S
Why the trial data drew so much attention Much of the interest around semaglutide comes from the SUSTAIN and STEP clinical programmes, where researchers evaluated outcomes relating to glycaemic control and body weight reduction in selected adult populations
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