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AMPK binds directly to FXR and represses the receptor via direct phosphorylation, resulting in reduced FXR transcriptional activity and, subsequently, reduced bile acid absorption [65]

1-6 Acute heavy metal intoxications may damage central nervous function, the cardiovascular and gastrointestinal systems, lungs, kidneys, liver, endocrine glands, and bones

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The accumulation of these tangles causes nerve cells to die, leading to the symptoms of memory loss associated with AD