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exenatide accumulates with significant kidney impairment, while semaglutide relies less on renal clearance

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With existing FDA approval and established safety profiles, this class of medications presents a promising opportunity for repurposing in addiction treatment

Clinical trials show sustained benefits over 72 weeks with continued GLP-1 and GIP receptor activation, though real-world treatment varies significantly based on patient-specific factors

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High-Throughput Screening In drug discovery and development, GST-tagged proteins are used in high-throughput screening (HTS) assays