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In colorectal cancer, IGF-2 secreted by cancer-associated fibroblasts binds to IGF-1R on cancer cells to activate the PI3K/AKT/mTOR and Hippo-YAP1 signaling pathways to promote cancer cell proliferation, migration and invasion

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Literature showed chromatin condensation, assessed by aniline blue staining, was significantly higher in the human ejaculated spermatozoa than in testicular sperm (34)