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Whilst several peptidesparticularly GLP-1 receptor agonists such as semaglutide and liraglutideshow promise in research settings for reducing liver fat, none are currently licensed by the MHRA specifically for treating fatty liver disease

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Repeated IM injections are painful and inconvenient, and other local side effects such as tissue irritation or fibrosis at injection sites are also concerns, leading to low long-term patient compliance ( 4.4 Intrathecal administration Intrathecal (IT) delivery involves administering the chelator directly into the CSF (often via lumbar puncture or an implanted reservoir), thereby bypassing the BBB ( Molecules administered by intrathecal administration still encounter barriers within the subarachnoid space for drug penetration from CSF into brain parenchyma, but IT dosing creates a favorable concentration gradient for drugs to diffuse

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Can J Physiol Pharmacol 89 , 497504, (2011)

With rising obesity rates and a growing population of metabolic disease patients, China is widely expected to become one of the most important future growth markets for GLP-1 therapies