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Key Insights Risk reduction over glucose-only targets : GLP-1 RAs deliver multi-system benefitsglycemia, weight loss , MACE reduction, renal protection aligned with ADA , ACC/AHA , and KDIGO Start GLP-1 before prandial insulin in over-basalized patients to tame postprandial spikes, drive weight loss, and reduce insulin requirements

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This novel dual-agonist approach surpassed the efficacy of monotherapy while maintaining a favorable costbenefit and safety profile [122]

In a world increasingly affected by digital fatigue, rising glucose dysregulation, and stress-driven metabolic imbalances, the demand for innovative support tools has never been more urgent

Leibowitz for critical review of the manuscript

2003, 284 (4): G588-G594