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Secondary endpoints assess impact on multiple co-morbidities, e.g., MACE-3 events, onset of T2D, hypertension, heart failure or renal disease

Hoelker, M., Schmoll, F., Schneider, H., Rings, F., Gilles, M., Tesfaye, D., Jennen, D., Tholen, E., Griese, J., and Schellander, K.: Bovine blastocyst diameter as a morphological tool to predict embryo cell counts, embryo sex, hatching ability and developmental characteristics after transfer to recipients, Reprod

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This is especially evident in conditions that affect both humans and animals (Kiani et al

J Neurochem 64:27732782 Ebert D, Haller RG, Walton ME (2003) Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy

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