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Some signs of bowel obstruction are abdominal pain or cramping, nausea, vomiting, decreased appetite, constipation, and abdominal distention

They also remain outside the scope of the FDAs interim enforcement discretion policy, which currently extends only to substances in Category 1

Reassuring clinical data are starting to accrue: two multinational population-based cohort studies found no increased risk of major congenital malformations, live births, pregnancy losses, and pregnancy terminations during the periconceptional period with GLP-1 RAs [139]

10.1016/j.semcancer.2019.03.002