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Hypoglycemia, cardiovascular outcomes, and death

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As weight decreases and blood pressure drops, some antihypertensive drugs may need to be reduced or discontinued to prevent hypotension (dangerously low blood pressure)

Survodutide and retatrutide phase 2 clinical trials in adults with MASLD and MASH show 60 to 80% relative reductions in intrahepatic triglyceride

Codon optimized sequences of NAPstar3b and HyPer7 for expression in mammalian cells were commercially synthesized ( Supplementary Table 4 ) (GenScript Biotech, Rijswijk, Netherlands) and delivered in pcDNA3.1(+) plasmids