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These xenobiotics disrupt tubular cell polarity which, along with the expression of apical and basolateral transporters, is crucial for tubular cell function

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RotroffDCorumDMotsinger-ReifAFiehnOBottrelNDrevetsWet alMetabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: New mechanistic insights for rapid acting antidepressants