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PMID: 206 WangXYuanWYangCWangZZhangJXuDet al

These interactions and mechanisms are comprehensively depicted in Fig

To enter this silent state, stress factors such as oxygen deprivation, limited nutrients, or chemical stress prompt changes in intracellular metabolism, allowing cancer cells to endure adverse conditions without being destroyed 12

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It is found in the cytosol and nucleus and has been linked to protein kinase C- signaling [30] and iron homeostasis [31]