[101] In April 2026, Dr
In patients with obesity, with or without diabetes, significant weight loss (and improvement in weight-related complications) has been consistently demonstrated 8,9,10
NICE recommends considering bariatric surgery for adults with a BMI of 40 kg/m or more, or between 35-40 kg/m with significant obesity-related conditions, with expedited consideration for those with recent-onset type 2 diabetes
Days one and two after injection often bring the most fatigue and strongest appetite suppression
When to Consider Testing Testing may be useful: Before starting a GLP-1 medicine After a meaningful treatment change When diabetes goals are not being met When persistent gastrointestinal symptoms develop When food or fluid intake has significantly decreased When kidney or liver risk is already present When a prior result was abnormal When a healthcare provider recommends follow-up Testing frequency should be based on individual risk rather than an automatic monthly or quarterly panel for everyone
Like all medicines, semaglutide can have some side effects, but most are minor and transient