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A mitochondrial switch ("SLC25A45") controls whether mitochondria burn fat or carbohydrate, and removing it (in mice) makes GLP-1 drugs stop working for fat loss entirely

Free Radic Biol Med (2018) 127:1604

Additionally, we proposed to perform a similar analysis using updated claims data, including determining if HCPCS codes G0562 and G0563 continue to meet the criteria for our universal low volume APC policy, in the CY 2026 OPPS/ASC final rule with comment period and update the APC assignments as needed

Patients considering or currently using weight loss injections understandably want clarity about safety

goal = 157 lb by 16 weeks

comparing the effect if all study participants used GLP-1RAs vs the effect if all participants used basal insulin