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Glucocorticoids: The Most Clinically Significant Interaction Glucocorticoids (prednisone, dexamethasone, hydrocortisone, budesonide) blunt the GH response to GHRH stimulation through at least three mechanisms: they increase hypothalamic somatostatin tone, they directly reduce somatotroph sensitivity to GHRH, and they suppress hepatic IGF-1 production independent of GH

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Ozempic (semaglutide) is a GLP-1 receptor agonist, meaning it imitates the functions of the intestinal hormone glucagon-like peptide-1 (GLP-1)

Notably, blocking lactate transport by inhibiting MCT1 or GPR81 promotes ferroptosis primarily through alterations in lipid metabolism rather than through conventional ferroptosis regulators, as evidenced by unchanged GPX4 and FSP1 levels (57)