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Temperatures above 77F (25C) accelerate semaglutide degradation, and exposing your injection to heat for extended periods can render it ineffective

The transition period from tirzepatide to retatrutide involves pharmacological overlap as the previous compound washes out and the new one reaches steady state

Possible side effects include nausea, bloating, lightheadedness, and dehydration, especially early in treatment

Prioritize protein (80-100g minimum daily), supplement essential micronutrients, and maintain aggressive hydration

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