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Clinical trials have shown that patients with high BMI treated with Semaglutide GLP-1 experienced significant weight loss

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Second: moving to GLP-2(Tirz) when the research question involves GIP receptor contribution or when a larger effect magnitude is needed without introducing the glucagon receptor variable

doi: 10.1016/j.bbi.2024.05.006 171 AtkinsonEAGregoryHNCarterLNEvansRERobertonVHDickmanRet al

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The FDA-approved maximum for weight loss is 2.4 mg weekly, though some patients achieve significant results at lower doses such as 0.5 mg, 1.0 mg, or 1.7 mg