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GLP-1 works by mimicking the action of a natural hormone called glucagon-like peptide-1

You have some wiggle room, but if you fall off your schedule for too long, those signs of fatigue will inevitably return, and they almost always arrive on the scene before any other symptom does

The result is a catch-22: patients must persist long enough to demonstrate clinical benefit, yet the financial burden often prevents that persistence, undermining the very outcomes needed to justify reimbursement

[Published correction appears in JAMA

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S Martins da Silva was not involved in the review or editorial process for this paper, on which she is listed as an author