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The sublingual route is a delivery mechanism that gets semaglutide into systemic circulation through mucous membranes, but this does not create the kind of oral fluid residue that saliva drug tests detect, and even if it did, the target antibodies in those tests would not respond to it

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Additionally, 41% of patients who used 8 mg retatrutide showed an improvement in blood pressure, and they had to discontinue at least one antihypertensive medication

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