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GLP-1 medications should not be taken by anyone with a personal history or family history of medullary thyroid cancer, as development of these tumors were noted during early animal studies

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The drug seems to turn the bodys metabolic gears by targeting pathways associated with fat utilization and glucose regulation

Both represent important advances in obesity medicine, and the most appropriate option depends on an individual's medical history , treatment goals , and a discussion with their healthcare provider

Both companies are also developing oral versions of GLP-1 medications

In Phase 2 trials, retatrutide was started at 12 mg subcutaneously once weekly and gradually titrated to maintenance doses of 4 mg, 8 mg, or 12 mg once weekly