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Regularly evaluate patients for signs and symptoms of OIED (e.g., dysphagia, regurgitation, non-cardiac chest pain), and if necessary, adjust opioid therapy as clinically appropriate

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Matrix Metalloproteinases (MMPs) and Their Inhibitors (TIMPs): The balance between MMPs (which break down the ECM) and TIMPs (which inhibit MMPs) is critical for tissue homeostasis

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