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Cagrilintide versus tirzepatide Tirzepatide produces the highest weight loss of currently approved medications, with trials showing 21 to 25% reduction over extended treatment periods

Int J Biochem Mol Biol

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Biodistribution and mucus penetration studies further confirmed strong colonic accumulation and excellent mucus permeability [123]

The mechanism that makes these medications effective, slowing gastric emptying, is also what puts pressure on the lower esophageal sphincter and invites reflux