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It was also previously shown that low XDH expression in breast cancer patients was associated with a lower disease-free survival (DFS) that was almost half the median survival time of patients with high XDH expression

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As shown in Figure 2, when an intracellular iron overload occurs, excess iron promotes lipid peroxidation through ROS production and Fenton reaction, thus causing ferroptosis ( TFRC gene encoding TRF1 inhibits erastin-induced ferroptosis and prevents LIP accumulation, while HO-1 promotes ferroptosis by supplementing iron (Kwon et al., 2015)