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Most injection site reactions are signals not failures
Still, more than 20 years passed from the approval of the first monoclonal antibody for the treatment of autoimmune diseases, non-Hodgkin lymphoma and chronic lymphocytic leukemia (Rituximab, 1997) until the approval of the first antibody for treatment of solid tumors (Sacituzumab Govitecan, 2020)
Initial doses are typically conservative to assess tolerability and tissue response before titration upward
Selenium: This mineral is a co-factor for the enzymes that use glutathione
doi: 10.1016/j.ddstr.2006.03.004
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