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Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

According to our proteomics analysis, GSR was overexpressed (NSAF ratio = 4.43, P = 0.00070)

Zeng F, Shi Y, Wu C, Liang J, Zhong Q, Briley K, et al

GSTM1 and GSTT1 null deletions mean those genes are completely absent producing zero enzyme activity rather than reduced activity

The TCA cycle fulfills other bio-energetic, biosynthetic, and redox balance requirements and functions as a metabolic hub

It ensures the factory has the workers it needs and prevents the finished product from being wasted on minor tasks