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J Clin Endocrinol Metab 94:846852 Nogueiras R, Perez-Tilve D, Veyrat-Durebex C et al (2009) Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity

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Patients with homozygous MTHFR C677T can have moderate (16-30umol/L) or intermediate (31-100umol/L) hyperhomocysteinemia

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In addition to normalizing glucose, butyrate treatment improved insulin sensitivity, demonstrated by lower insulin levels required to maintain low basal glucose

Discussion The aim of our study was to show, for the first time, the effects of pycnogenol in preventing CP-induced uterine and ovarian damage