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Cardiologists now have an ever-expanding armamentarium to treat HFpEF." In a secondary analysis of the SUMMIT trial, also presented at AHA 2024 and published in JACC , researchers looked at the effect of tirzepatide on cardiac structure and function in 106 patients from the main SUMMIT study

Altogether, our data demonstrate that sUA, released in the context of ureteral obstruction, is responsible for triggering inflammation and for consequent induction of fibrosis, in a Myd88 - and Nlrp3 - dependent manner

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