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10.1172/jci.insight.169125 201 YuW.YinS.TangH.LiH.ZhangZ.YangK

The surgical alterations permanently compromise b12 absorption through multiple mechanisms

Its effects stay focused on adipose tissue: AOD9604 stimulates lipolysis primarily through beta3 adrenergic receptor pathways in adipose tissue, driving the breakdown of stored triglycerides into free fatty acids

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However, even when combined with chemotherapy, personalized vaccination did not result in significant survival differences, as demonstrated in the treatment of CRPC with personalized autologous dendritic-cell-based cancer vaccine (DCvac) plus docetaxel [171]