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Wegovy, a leading option, has shown a significant average weight loss of 14.9% in clinical trials

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Gastaldelli A, Cusi K, Fernndez Land L, Bray R, Brouwers B, Rodrguez (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

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Semaglutide should be used via subcutaneous injection (or oral form in certain formulations) with gradual dose escalation and concurrent lifestyle support (diet, exercise) to maximize benefit and minimize GI side effects