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In some cases, the request may be denied, in which case the healthcare provider can appeal the decision, which may add additional time to the process

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In experimental models, silymarin, when administered in doses equivalent to about 220 mg to 2.2 g daily for an adult human, protected kidney cells and rat kidneys from damage caused by toxin overdose (Rastogi 2001

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As you lose weight on the combination, blood sugar may drop more than expected, creating a risk of hypoglycemia that requires more frequent monitoring and potential dose adjustments