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[DOI] [PubMed] [Google Scholar] 93.Smelt H.J.M., Pouwels S., Smulders J.F., Hazebroek E.J

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In rodents, especially mice, the increased DNA content that represents the biochemical effect of hyperplasia may occur by changes in cellular ploidy without actual cytokinesis

Metabolic and safety outcomes Regarding metabolic outcomes, combination therapy demonstrated significantly greater weight loss compared to SGLT-2i monotherapy (MD = 2.20, 95% CI 3.09