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KPV studies report effective anti-inflammatory concentrations in cell culture models at nanomolar to low micromolar ranges [7]

Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary

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In addition, mutations in ALDH7A1 in the lysine degradation pathway can also cause epilepsy that responds to P5P supplementation.[ref] Regulation of active B6: The cellular levels of P5P are fairly tightly regulated in the body with feedback loops and mechanisms in place

PMID 16801493

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