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We further identified that HZRG enhanced fecal BA excretion via inhibiting IBAT, and the modulation of BA profiles, gut dysbiosis as well as the intestinal environment all contributed to the beneficial effects of HZRG on NASH mice

In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision

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The two ratios most often described in community sources are below