The MHRA approved tirzepatide following clinical trials demonstrating superior glycaemic control and weight loss compared to other GLP-1 receptor agonists
How are GLP-1 drugs changing what people eat
The most effective balance involves spacing coffee at least one hour before or two hours after iron-rich meals and supplements
2 In addition to lifestyle modifications (diet and exercise), many pharmacologic strategies have been proposed to counter iatrogenic weight gain, including appetite suppressants (eg, pro-dopaminergic agents such as phentermine, stimulants, and amantadine), pro-anorectant anticonvulsants (eg, topiramate or zonisamide), opioid receptor antagonists (eg, olanzapine/samidorphan or naltrexone) and oral hypoglycemics such as metformin
The primary objective of the phase 3b SOUL trial was to evaluate the effects of oral semaglutide 14 mg, in addition to standard of care, on reducing the risk of MACE in adults with type 2 diabetes at high risk for major cardiovascular events
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