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Sodium-glucose cotransporter 2 (SGLT2) inhibitors have demonstrated both kidney- and heart-protective effects in individuals with CKD, and other agents, such as non-steroidal mineralocorticoid receptor antagonists (ns-MRA), provide cardio-kidney protection in patients with diabetes and kidney disease

Wang JY, Abbas MA

One enzyme, glutathione peroxidase (GPx), works with glutathione to prevent cell membranes from becoming oxidized, which would otherwise lead to cell death

Another aspect is the presence of heavy metals

It is thought that an important underlying pathogenetic basis for the metabolic syndrome is insulin resistance and accompanying compensatory hyperinsulinemia[301]

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