In total 145 proteins were differentially expressed at a log 2 (fold-change) cutoff of 1 and a false discovery rate (FDR) of 10 1
Gomez DR, Blumenschein GR Jr, Lee JJ, Hernandez M, Ye R, Camidge DR, Doebele RC, Skoulidis F, Gaspar LE, Gibbons DL, Karam JA, Kavanagh BD, Tang C, Komaki R, Louie AV, Palma DA, Tsao AS, Sepesi B, William WN, Zhang J, Shi Q, Wang XS, Swisher SG , Heymach JV
Even a cursory read through the established facts is pretty shocking
Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011
I do wonder if my pain perception was being dampened by the B12 deficiency and so now Im feeling pain more (period cramps are also worse now) but I guess Ill just have to learn to live with that
Bee and wasp sting reactions in current beekeepers
