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C., Coughlan, M

The study also found that after semaglutide intervention, the food intake of obese mice decreased significantly, achieved by regulating appetite-related factors in the hypothalamus, indicating that semaglutide could penetrate the blood-brain barrier to reach the hypothalamus, brainstem, and arcuate nucleus through peripheral administration (Martins et al., 2022)

Am J Physiol Heart Circ Physiol 2011;300:H2H12

The patches sit at around 3.4 stars on Trustpilot, with reviews split between people who report feeling less hungry and people who saw no effect after a month or more of consistent use

Theres no requirement to separate them