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GLP-1RAs may help alleviate myocardial damage linked to chronic hyperglycaemia

When taking semaglutide, this discomfort might be due to bloating, gas, or reflux, which are known side effects of the drug

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Another two longer-acting analogs, glepaglutide and apraglutide, are currently undergoing phase III clinical trials

Specifically, local ghrelin injections to the ventral tegmental area (VTA) and laterodorsal tegmental area 27,40,41 as well as central administration to the lateral or third ventricle 27,42 increased extracellular dopamine in the nucleus accumbens (NAcc)

Low Hypoglycemia Risk Because both GIPR and GLP-1R stimulation is glucose-dependent, the insulin secretory response attenuates as blood glucose falls toward euglycemia [6]