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However, little is known about which of these agents and mechanisms would be appropriate to target highly heterogenous HR-NB in a clinically relevant setting, such as how they interact with chemotherapy and if they can be implemented as part of the current standard-of-care chemotherapeutic regimes

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It may not bind its target receptor at all, and any published data on the tesamorelin + ipamorelin blend half life assumes you're injecting the intact, correctly folded molecule

The answer is yes , it really can