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Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity

No controlled study has tested either protocol in humans, and no study has compared them head-to-head

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doi: 10.1097/01.ju.0000060564.31122.2a

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Rahman, Environmental toxicity, redox signaling and lung inflammation: The role of glutathione Molecular Aspects of Medicine, 2009