As we briefly touched on before, glutathione is no stranger to the pharmaceutical industry
While KYN itself is not neuroactive, it is a branching point for two major metabolic routes: one leading to the synthesis of kynurenic acid (KYNA), which occurs in astrocytes, and another leading to the synthesis of picolinic acid (PA) and quinolinic acid (QA), occurring in microglia, with QA serving as a precursor for nicotinamide adenine dinucleotide (NAD) [25, 26]
Medically reviewed by: Jayden Lee, PharmD, EMBA Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes
This thiol group is reactive and can donate a hydrogen atom to neutralize free radicals and other reactive oxygen species, thereby protecting cells from oxidative stress
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GPX1-4 and GPX6 are neutral to selenocysteine, so they can mediate redox reactions by interacting with GSH (Figures 1, 8)