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5.4 Experimental validation of epigenetic mechanisms Recent technological advances in genome editing and single-cell analysis have provided powerful tools to validate EED-induced epigenetic modifications as causal mechanisms underlying transgenerational reproductive toxicity

Crosstalk between growth factors and estrogens may be responsible for the development of estrogen-independent BrCa tumors [104]

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Similarly, common types of gastric premalignant lesions are comprised of gastric ulcers, gastric polyps, atrophic gastritis, intestinal metaplasia, etc