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Rare but serious adverse effects require immediate action: Acute pancreatitis : Seek emergency medical attention if you develop severe, persistent abdominal pain radiating to the back, often accompanied by nausea and vomiting Gallbladder disease : Rapid weight loss increases the risk of gallstone formation

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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice