Its all about knowing who can join the party and where the fine print lurks, so youre not blindsided
These data offer an additional mechanism for GLP-1R signaling regulation of the reinforcing and rewarding properties of cocaine without precluding the possibility that GLP-1R signaling may also affect DA release and firing properties of VTA neurons
The amino acid sequence of the peptide itself is unchanged
Other clinical bispecific mAbs, retaining the Fc for half-life extension, require additional mutations, including in the CH3 domain of the Fc to generate heterodimers (e.g., Fab-arm exchange/knobs-into-holes), as well as LALA or STR mutations to limit endogenous FcR interaction
Is it a conflict of interest
The cash price for a one-month supply of Ozempic or Wegovy in the United States can be well over $1,300