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It describes the shape of the molecule, not the delivery method

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Studies have shown that EGCG has a great ability to safeguard the skin from photoinduced destruction, which is the chief principle of cancerous skin, and that skin photo protection is a highly significant component in preventing skin cancer [39]

It is that metformin has been evaluated within a far more stringent system, and obtaining it requires a prescription, whereas berberine is subject to far less scrutiny and is available to order online with no medical oversight or third-party quality control checking the purity of the ingredients