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In HFD-fed Atg7 cKO mice and Parkin KO mouse models, some investigators found that deletion of Atg7 and Parkin inhibited mitophagy increased lipid accumulation, and exacerbated diastolic dysfunction, whereas injection of Tat-Beclin1 (TB1) increased mitophagy and attenuated cardiac dysfunction [174]

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10.1083/jcb.104.3.527 70 LubinB.ChiuD.BastackyJ.RoelofsenB.Van DeenenL

10.1016/j.jmig.2007.06.003 136 YuL.SaileK.SwartzC