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Free Radic Biol Med 14:649653 Sheehan D, Meade G, Foley VM, Dowd CA (2001) Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

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Conclusions: The trajectory of semaglutide exemplifies how intentional peptide design, iterative translational research, and outcome-driven clinical trial design can lead to groundbreaking therapies for complex metabolic disorders

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Hyperglycemia-mediated disruption of carnitine reabsorption Chronic hyperglycemia, a key of driver DKD, impairs renal carnitine homeostasis by directly disrupting reabsorption in proximal tubules [94]