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The most frequent adverse events reported were nausea, constipation, fatigue, decreased appetite, injection site erythema, and injection site reaction, followed by vomiting, headache, diarrhea, dyspepsia, and nasopharyngitis (Table 3)

Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis

Small molecules can have different storage and handling requirements than peptides

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Thanks to the distinct characteristics of nanoparticles which include improved targeting, ability to control the drug release and low toxicity in the systemic circulation, the nanotechnology allows for precise regulation of oxidative stress in tumour cells [40,41,42]