In rat fertility studies with oral gavage doses of 125, 250, and 1000 mg/kg, males were treated for 4 weeks prior to mating, during mating, up to scheduled termination (approximately 8 weeks total), and females were treated 2 weeks prior to mating through gestation day 7
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Estn diseados para apoyar la actividad natural del GLP-1 en el organismo, en lugar de replicar los medicamentos recetados (7)
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Its administration is typically via subcutaneous injection once weekly, and dosing in clinical trials has ranged from 0.5 mg to 12 mg, adjusted to optimize efficacy and tolerability
Estos medicamentos imitan los efectos de la hormona natural pero con duracin extendida, lo que permite su uso teraputico en diabetes tipo 2 y obesidad.