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Together these data indicate that although vagal afferent neurons may contribute to hypophagia induced by peripheral administration of GLP-1R analogs, these neurons are not necessary for the hypophagic effect

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The results of the TRANSCEND-T2D-1 trial, published in March 2026, showed that participants with type 2 diabetes mellitus, who took retatrutide 12mg, lost an average of 16.8% of their body weight at 40 weeks

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A review published in Diabetes, Obesity and Metabolism found that semaglutide reduced the rate of gastric emptying by up to 27% compared to placebo

It's regulated under DSHEA, not the FDA drug approval pathway