So, proinflammatory and procoagulant proteins, including HMGB1, TNF?, ICAM1 and NFkB, disrupt the BBB and tight junction proteins, including ZO-1, occludin and claudin-5, are critical for the formation and maintenance of BBB integrity
It catalyzes the dismutation of superoxide radical into oxygen and hydrogen peroxide [82]
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Disclosure: I prescribe many of the medications I discuss in this newsletter
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